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posaconazole will boost the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
drospirenone will enhance the amount or result of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Mysterious.
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In 2008, Cephalon compensated $425m and pleaded responsible to some federal legal charge relating to its promotion of off-label takes advantage of for Provigil and two other drugs. ^
Observe Intently (one)voriconazole will raise the amount or result of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
modafinil will boost the amount or influence of clobazam by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Keep an eye on. Dosage adjustment may very well be necessary; CYP2C19 inhibitors might end in improved publicity to N-desmethylclobazam (active metabolite).
While the total choice of modafinil’s opportunity drug interactions isn't nevertheless wholly regarded, quite a few early experiments have documented probable adverse interactions among modafinil and the next medication as well as other compounds [78, seventy nine]:
Dose adjustments of these medications and also other medicines which have been substrates for CYP2C19 might be required if modafinil is coadministered
phenytoin will reduce the level or effect of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
fosphenytoin will lower the extent or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Stay clear of or Use Alternate Drug. Stay clear of coadministration of delicate CYP3A4 substrates with ivosidenib or swap with alternate therapies. If coadministration is unavoidable, observe clients for lack of therapeutic impact of such medicines.
While modafinil is generally located to be Protected and significant adverse effects are rare, such as in pediatric narcolepsy situations (slumber Ailments in kids), There exists evidence that extended-term use can cause tolerance in a few folks.
Take this medication only as directed by your doctor. Tend not to take far more of it, click here never just take it a lot more generally, and don't take it for an extended time than your medical doctor ordered. If excessive is taken, it could turn into routine-forming.